Formulation: A solution in ethanol
Formal Name: didodecyl 3,3'-((3-(2-amino-3-(1H-imidazol-4-yl)propanamido)propyl)azanediyl)dipropionate
Purity: ≥95%
Formula Markup: C39H73N5O5
Formula Weight: 692
Shelf life (days): 1460
Notes: O12-D3-I3 is an ionizable cationic lipid (pKa = 6.39) that has been used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo.{67932} LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting nuclear factor erythroid 2-related factor 2 (Nrf2) or the system xc- cystine/glutamate transporter decrease viability of HepG2 hepatocellular carcinoma cells. LNPs containing O12-D3-I3 and an mRNA reporter selectively accumulate in the tumor and liver over the lungs, kidneys, spleen, and heart in an MCF-7 breast cancer mouse xenograft model. LNPs containing O12-D3-I3 and encapsulating ferrocene and either Nrf2-targeting siRNA or system xc- cystine/glutamate transporter-targeting siRNA reduce tumor growth and volume in an MCF-7 mouse xenograft model. LNPs containing O12-D3-I3 and encapsulating siRNA targeting Factor VII decrease hepatocyte Factor VII mRNA levels in mice.
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