PAMAM Dendrimer G0.5 Carboxylate (sodium salt) (water solution), CAS 339334-01-9

Formulation: A solution in water

Formal Name: 11,14-bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]-4,21-bis(2-carboxyethyl)-8,17-dioxo-4,7,11,14,18,21-hexaazatetracosanedioic acid, octasodium salt

Formula Markup: C46H72N10O20 • 8Na

Formula Weight: 1269,1

Shelf life (days): 730

CAS Number: 339334-01-9

Notes: PAMAM dendrimer G0.5 carboxylate (PAMAM G0.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini.{67553} It is approximately 27.9 Å in diameter in water and has 8 surface groups.{67554} Conjugates of PAMAM G0.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.03, 1.6, 0.18, and 3 µM, respectively).

• SKU: CAY39104-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39104-500
• Green Labware: No
• Package Unit: 500 mg
• Quantity Unit: STK