Formulation: A solution in ethanol
Formal Name: 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoic acid, 1-octylnonyl ester
Purity: ≥98%
Formula Markup: C44H87NO5
Formula Weight: 710,2
Shelf life (days): 365
CAS Number: 2089251-47-6
Notes: SM-102 is an ionizable cationic lipid (pKa = 6.68) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and plasmid DNA in vitro and in vivo.{61317,49885} It inhibits inward-rectifying potassium currents mediated by human-ether-a-go-go (hERG), also known as Kv11.1, in GH3 rat pituitary cells and MA-10 mouse Leydig cells (IC50s = 108 and 98 µM, respectively).{49886} Administration of luciferase mRNA in SM-102-containing LNPs induces hepatic luciferase expression in mice.{61317} LNPs containing SM-102 and Q1-SM-102 (Item No. 41239) as a cationic lipid pair (CLP) and encapsulating a luciferase reporter induce luciferase expression in the lungs and spleen in mice.{51839} Intramuscular immunization of LNPs containing SM-102 and encapsulating mRNA encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increases serum SARS-CoV-2 spike glycoprotein-specific IgG titers in mice.{49887} LNPs containing SM-102 and encapsulating mRNA encoding β-catenin increase bone volume in a mouse model of tibia fracture repair when administered via injection to the fracture callus.{49888} Formulations containing SM-102 have been used in the development of LNPs for delivery of mRNA-based vaccines. Read our statement on SM-102 for research use only
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