YHS-12, CAS 2959463-68-2

Formulation: A solid

Formal Name: (2E)-N1,N4-bis[2-(didodecylamino)ethyl]-2-butenediamide

Purity: ≥95%

Formula Markup: C56H112N4O2

Formula Weight: 873,5

Shelf life (days): 1460

CAS Number: 2959463-68-2

Notes: YHS-12 is an ionizable cationic lipid (pKa = 6.506) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.{68845} LNPs containing YHS-12 and the macrophage targeting peptide CRVLRSGSC and encapsulating mRNA encoding chimeric antigen receptor targeting methicillin-resistant S. aureus (MRSA) and siRNA targeting caspase-11 increase the phagocytosis rate of MRSA in RAW 264.7 macrophages and primary mouse bone marrow-derived macrophages (BMDMs). Intravenous administration of these LNPs decreases blood bacterial burden and increases survival in a model of sepsis using cyclophosphamide-induced immunosuppressed mice.

• SKU: CAY40510-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40510-10
• Package Unit: 10 mg
• Quantity Unit: STK