Notes: Q1-ALC-0315 is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (Item No. 34337) that has been used in the generation of lipid nanoparticles (LNPs) for use in vivo.{51839} LNPs containing Q1-ALC-0315 and ALC-0315 as a cationic lipid pair (CLP) and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice.