Clone: GP1.4
Background: Episialin is also known as MUC1, MAM-6, CA 15-3, PEM and EMA. It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms geneRated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. The gene encoding episialin (MUC1) is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. Episialin is present in several secretory epithelial cell types.
Source: GP1.4 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with human milk fat globule.
Specificity: GP1.4 reacts with all glycoforms of Episialin. The exact epitope is described in reference 4 and covers the amino acid sequence PDTRPAPGS
References: 1. Gourevitch, M. M., von Mensdorff-Pouilly, S., Litvinov, S. V., Kenemans, P., van Kamp, G. J., Verstraeten, A. A., and Hilgers, J. (1995). Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients. Br J Cancer 72, 934-938. 2. Norum, L. F., Varaas, T., Kierulf, B., and Nustad, K. (1998). Carcinoma-associated MUC1 detected by immunoradiometric assays. Tumour Biol 19, 134-146. 3. Norum, L. F., Sauren, A. M., Rye, P. D., and Nustad, K. (2001). New immunoassays for MUC1 in breast cancer, Tumour Biol 22, 216-22.4. Cao Y, Karsten U. Binding patterns of 51 monoclonal antibodies to peptide and carbohydrate epitopes of the epithelial mucin (MUC1) on tissue sections of adenolymphomas of the parotid (Warthin's tumours): role of epitope masking by glycans. Histochem Cell Biol. 2001 Apr;115(4):349-56.
UniProt: P15941
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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