Clone: Edu-2
Background: CD4 (Cluster of Differentiation 4) is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene. CD4 plays a role in the recognition of foreign antigens presented to T cells by MHC class II molecules. Furthermore, this antigen acts as a receptor for HIV-1 by binding the viral protein gp120. The CD4 antigen is present on most thymocytes and a subpopulation of peripheral blood T cells, called T helper cells (Th). In addition, CD4 is expressed on monocytes and weak on macrophages.
Source: Edu-2 is a mouse monoclonal IgG2a antibody raised against CD4.
Specificity: CD4 (Edu-2) recognizes the CD4 antigen (a 55 kD glycoprotein).
Formulation: Each vial contains 1 ml of 100µg/ml purified monoclonal antibody in 0.01 M sodium phosphate, 0.15 M NaCl, 0.2% BSA, 0.09% sodium azide; pH 7.3.
References: 1. Carrière, D., et al., 1995, In: Leukocyte Typing V: 475-476. 2. Piatier-Tonneau, D., et al.,1995, In: Leukocyte Typing V: 476-478. 3. Kaneoka, H. et al., 1983. J. Immunol., 131: 158 4. Lanier, L.L., et al., 1986. J. Immunol., 137: 2501 5. Knowles, R.W., 1986. In: Leukocyte Typing II : 259-288; 6. E.L. Reinhert, B.F. Haynes, L.M. Nadler/ and I.D. Bernstein, eds. Springer-Verlag, New York 7. Friedrich, W., 1982. Blood, 59: 696 8. Allison, J.P. and Lanier, L.L., 1987. Ann. Rev. Immunol., 5: 503
UniProt: P01730
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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