Clone: 33A10
Background: The 33A10-defined antigen is the orphan protein, Placenta expressed transcript (Plet)-1. Biochemical data indiCated that Plet-1 is a glycosylphosphatidylinositol-anchored glycoprotein with N-linked carbohydRates in addition to other posttranslational modifiCations. Plet-1 is a a recently identified protein that as of yet has no known function and is not associated with any one family of proteins. Plet-1 is used as a cell surface marker present on stem/progenitor epithelial cells and in a number of tissues including thymus and skin, and on epithelial cell types in mammary gland, prostate, and pancreas.
Source: 33A10 is a Rat IgG2b monoclonal antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells of Sprague-Dawley Rats immunized with Mouse mammary tumor cells.
Specificity: 33A10 reactivity is identified in the developing Mouse mammary gland, in the bronchioles of the lung, the salivary glands and the skin. Plet-1 is a product specific for Keratinocytes undergoing terminal trichilemmal differentiation in the hair follicle and is expressed at the plasma membranes.
Formulation: Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
References: 1. A Sonnenberg, H Daams, M A Van der Valk, J Hilkens and J Hilgers (1986), J Histochem Cytochem 34 (8): 1037-1046. 2. Karine Raymond, Anja Richter, Maaike Kreft, Evelyne Frijns, Hans Janssen, Monique Slijper, Silke Praetzel-Wunder, Lutz Langbein and Arnoud Sonnenberg (2010), J Invest Derm 130 1500-1513.
UniProt: Q8VEN2
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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