Description: DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.
MCE owns a unique collection of 2001 cell cycle/DNA damage-related compounds which can be used in the research of the same.
MCE Cell Cycle/DNA Damage Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1943 compounds supplied in 10 mM solution, 51 compounds supplied in 2 mM solution and 7 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
Advantages:
- A unique collection of 2001 Cell Cycle/DNA Damage related compounds for high throughput screening (HTS) and high content screening (HCS).
- Targets such as CDK, ROCK, Aurora Kinase, ATM/ATR, DNA-PK, DNA/RNA Synthesis, etc.
- A useful tool to study the mechanism of cell cycle regulators that are critical to normal development and the development of cancer, cardiovascular, inflammatory, and neurodegenerative diseases.
- Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.
- Structurally diverse, medicinally active, and cell permeable.
- More detailed compound information with structure, IC50, and other chemical & biological data.
- NMR and HPLC validated to ensure high purity and quality.
- All compounds are in stock and continuously updated.
Formulation: A collection of 2001 Cell Cycle/DNA Damage related compounds supplied as pre-dissolved Solutions or SolidSolution:1943 compounds supplied in 10 mM solution,51 compounds supplied in 2 mM solution,7 compounds supplied in 3 mg/mL solution.
Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.
Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
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