Chemokine Compound Library

Chemokine Compound Library
SKU
MEXHY-L132-30
Packaging Unit
30 μl
Manufacturer
MedChemExpress

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Description: Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.
Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.
The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases.
MCE supplies a unique collection of 146 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.
MCE Chemokine Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 143 compounds supplied in 10 mM solution and 3 compounds supplied in 2 mM solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

Advantages:
  • A unique collection of 146 Chemokine or Chemokine receptor inhibitors and activators for high throughput screening (HTS) and high content screening (HCS).
  • A useful tool for studying the relationship between diseases and Chemokine or Chemokine receptor.
  • Target diverse, medicinally active and cell permeable.
  • Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
  • More detailed compound information with structure, IC50, and other chemical & biological data.
  • High purity and quality validated by NMR and LC/MS.


Formulation: A collection of 146 chemokine or chemokine receptor related compounds supplied as pre-dissolved Solutions or SolidSolution:143 compounds supplied in 10 mM solution,3 compounds supplied in 2 mM solution.

Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.

Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
More Information
SKU MEXHY-L132-30
Manufacturer MedChemExpress
Manufacturer SKU HY-L132-30
Green Labware No
Package Unit 30 μl
Quantity Unit STK
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