Description: GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.
GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.
MCE provides a unique collection of 2286 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.
MCE GPCR/G Protein Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 2255 compounds supplied in 10 mM solution and 31 compounds supplied in 2 mM solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.
Advantages:
- A unique collection of 2286 small molecules targeting G protein coupled receptors used in GPCR screening for various research and drug development projects.
- Targets such as 5-HT Receptor, Dopamine Receptor, Opioid Receptor, Adrenergic Receptors, Cannabinoid Receptor, mGluR, ETA Receptor, etc.
- The most successful class of drugable targets in the human genome and remain the most attractive family of targets.
- All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity. Some compounds have been approved by the FDA.
- A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery.
- Structurally diverse, medicinally active, and cell permeable.
- Rich documentation with structure, IC50, and brief introduction.
- NMR and HPLC validated to ensure the highest purity.
- All compounds are in stock and continuously updated.
Formulation: A collection of 2286 GPCR/G Protein related compounds supplied as pre-dissolved Solutions or SolidSolution:2255 compounds supplied in 10 mM solution,31 compounds supplied in 2 mM solution.
Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.
Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
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