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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: LCK is a tyrosine kinase that phosphorylates the CD3 receptor and is essential for T cell development and activation. LCK also associates with the cytoplasmic domains of the CD4 and CD8 glycoproteins and interacts with the beta-chain of the interleukin-2 receptor. LCK inhibitors are being investigated as a promising therapeutic approach to autoimmune disease and other inflammatory disorders.
Description: The LCK Assay Kit is designed to measure LCK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The LCK Assay Kit comes in a convenient 96-well format, with enough purified recombinant LCK, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 96 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: 1. Yu, C.-L., Jove, R., and Burakoff, S.J. 1997. "Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the LCK protein tyrosine kinase." J. Immunology 159 (11): 5206-5210.2. Veillette, A., et al. 1989. "Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56LCK." Nature 338(6212): 257-259.
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