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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: Mouse RIPK1 is a member of the receptor-interacting protein kinase (RIP) family. It plays an important role in cell survival as well as cell death, including apoptosis and necroptosis. RIPK1 is highly expressed in human Alzheimer's disease (AD) brains and in AD mouse models. Importantly, it was shown that inhibition of RIPK1 results in decreased amyloid and inflammation levels as well as accelerated amyloid beta peptide (Aβ) degradation by microglia in vitro.
Description: The Mouse RIPK1 Kinase Assay Kit is designed to measure Mouse RIPK1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The Mouse RIPK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant Mouse RIPK1 enzyme, RIPK1 substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: Ofengeim D., et al. Proc. Natl. Acad. Sci. USA 114(41): E8788-E8797 (2017)
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