CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. palladin 140 kDa CRISPR Activation Plasmid (m2)
    palladin 140 kDa CRISPR Activation Plasmid (m2)
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    Sku SACSC-437350-ACT-2
    Manufact. Skusc-437350-ACT-2
    Packaging Unit20 µg
  2. palladin 140 kDa CRISPR Activation Plasmid (m)
    palladin 140 kDa CRISPR Activation Plasmid (m)
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    Sku SACSC-437350-ACT
    Manufact. Skusc-437350-ACT
    Packaging Unit20 µg
  3. palladin 140 kDa CRISPR/Cas9 KO Plasmid (m)
    palladin 140 kDa CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-437350
    Manufact. Skusc-437350
    Packaging Unit20 µg
  4. eIF2C1 CRISPR Activation Plasmid (m2)
    eIF2C1 CRISPR Activation Plasmid (m2)
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    Sku SACSC-437349-ACT-2
    Manufact. Skusc-437349-ACT-2
    Packaging Unit20 µg
  5. eIF2C1 CRISPR Activation Plasmid (m)
    eIF2C1 CRISPR Activation Plasmid (m)
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    Sku SACSC-437349-ACT
    Manufact. Skusc-437349-ACT
    Packaging Unit20 µg
  6. eIF2C1 CRISPR/Cas9 KO Plasmid (m)
    eIF2C1 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-437349
    Manufact. Skusc-437349
    Packaging Unit20 µg
  7. MLL3 CRISPR Activation Plasmid (m2)
    MLL3 CRISPR Activation Plasmid (m2)
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    Sku SACSC-437348-ACT-2
    Manufact. Skusc-437348-ACT-2
    Packaging Unit20 µg
  8. MLL3 CRISPR Activation Plasmid (m)
    MLL3 CRISPR Activation Plasmid (m)
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    Sku SACSC-437348-ACT
    Manufact. Skusc-437348-ACT
    Packaging Unit20 µg
  9. MLL3 CRISPR/Cas9 KO Plasmid (m)
    MLL3 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-437348
    Manufact. Skusc-437348
    Packaging Unit20 µg
  10. Vimentin CRISPR Activation Plasmid (canine2)
    Vimentin CRISPR Activation Plasmid (canine2)
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    Sku SACSC-437347-ACT-2
    Manufact. Skusc-437347-ACT-2
    Packaging Unit20 µg
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