CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. Smok3b CRISPR/Cas9 KO Plasmid (m)
    Smok3b CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436922
    Manufact. Skusc-436922
    Packaging Unit20 µg
  2. Ripply1 CRISPR Activation Plasmid (m2)
    Ripply1 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436921-ACT-2
    Manufact. Skusc-436921-ACT-2
    Packaging Unit20 µg
  3. Ripply1 CRISPR Activation Plasmid (m)
    Ripply1 CRISPR Activation Plasmid (m)
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    Sku SACSC-436921-ACT
    Manufact. Skusc-436921-ACT
    Packaging Unit20 µg
  4. Ripply1 CRISPR/Cas9 KO Plasmid (m)
    Ripply1 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436921
    Manufact. Skusc-436921
    Packaging Unit20 µg
  5. AKR1C12 CRISPR Activation Plasmid (m2)
    AKR1C12 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436920-ACT-2
    Manufact. Skusc-436920-ACT-2
    Packaging Unit20 µg
  6. AKR1C12 CRISPR Activation Plasmid (m)
    AKR1C12 CRISPR Activation Plasmid (m)
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    Sku SACSC-436920-ACT
    Manufact. Skusc-436920-ACT
    Packaging Unit20 µg
  7. AKR1C12 CRISPR/Cas9 KO Plasmid (m)
    AKR1C12 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436920
    Manufact. Skusc-436920
    Packaging Unit20 µg
  8. KCTD21 CRISPR Activation Plasmid (m2)
    KCTD21 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436919-ACT-2
    Manufact. Skusc-436919-ACT-2
    Packaging Unit20 µg
  9. KCTD21 CRISPR Activation Plasmid (m)
    KCTD21 CRISPR Activation Plasmid (m)
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    Sku SACSC-436919-ACT
    Manufact. Skusc-436919-ACT
    Packaging Unit20 µg
  10. KCTD21 CRISPR/Cas9 KO Plasmid (m)
    KCTD21 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436919
    Manufact. Skusc-436919
    Packaging Unit20 µg
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