CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. ACPT CRISPR/Cas9 KO Plasmid (m)
    ACPT CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436852
    Manufact. Skusc-436852
    Packaging Unit20 µg
  2. Vmn2r62 CRISPR Activation Plasmid (m2)
    Vmn2r62 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436851-ACT-2
    Manufact. Skusc-436851-ACT-2
    Packaging Unit20 µg
  3. Vmn2r62 CRISPR Activation Plasmid (m)
    Vmn2r62 CRISPR Activation Plasmid (m)
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    Sku SACSC-436851-ACT
    Manufact. Skusc-436851-ACT
    Packaging Unit20 µg
  4. Vmn2r62 CRISPR/Cas9 KO Plasmid (m)
    Vmn2r62 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436851
    Manufact. Skusc-436851
    Packaging Unit20 µg
  5. Vmn1r170 CRISPR Activation Plasmid (m2)
    Vmn1r170 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436850-ACT-2
    Manufact. Skusc-436850-ACT-2
    Packaging Unit20 µg
  6. Vmn1r170 CRISPR Activation Plasmid (m)
    Vmn1r170 CRISPR Activation Plasmid (m)
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    Sku SACSC-436850-ACT
    Manufact. Skusc-436850-ACT
    Packaging Unit20 µg
  7. Vmn1r170 CRISPR/Cas9 KO Plasmid (m)
    Vmn1r170 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436850
    Manufact. Skusc-436850
    Packaging Unit20 µg
  8. Vmn1r176 CRISPR Activation Plasmid (m2)
    Vmn1r176 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436849-ACT-2
    Manufact. Skusc-436849-ACT-2
    Packaging Unit20 µg
  9. Vmn1r176 CRISPR Activation Plasmid (m)
    Vmn1r176 CRISPR Activation Plasmid (m)
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    Sku SACSC-436849-ACT
    Manufact. Skusc-436849-ACT
    Packaging Unit20 µg
  10. Vmn1r176 CRISPR/Cas9 KO Plasmid (m)
    Vmn1r176 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436849
    Manufact. Skusc-436849
    Packaging Unit20 µg
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