CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. Vmn1r34 CRISPR Activation Plasmid (m)
    Vmn1r34 CRISPR Activation Plasmid (m)
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    Sku SACSC-436845-ACT
    Manufact. Skusc-436845-ACT
    Packaging Unit20 µg
  2. Vmn1r34 CRISPR/Cas9 KO Plasmid (m)
    Vmn1r34 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436845
    Manufact. Skusc-436845
    Packaging Unit20 µg
  3. Olfr455 CRISPR Activation Plasmid (m2)
    Olfr455 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436844-ACT-2
    Manufact. Skusc-436844-ACT-2
    Packaging Unit20 µg
  4. Olfr455 CRISPR Activation Plasmid (m)
    Olfr455 CRISPR Activation Plasmid (m)
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    Sku SACSC-436844-ACT
    Manufact. Skusc-436844-ACT
    Packaging Unit20 µg
  5. Olfr455 CRISPR/Cas9 KO Plasmid (m)
    Olfr455 CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436844
    Manufact. Skusc-436844
    Packaging Unit20 µg
  6. CCDC42B CRISPR Activation Plasmid (m2)
    CCDC42B CRISPR Activation Plasmid (m2)
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    Sku SACSC-436843-ACT-2
    Manufact. Skusc-436843-ACT-2
    Packaging Unit20 µg
  7. CCDC42B CRISPR Activation Plasmid (m)
    CCDC42B CRISPR Activation Plasmid (m)
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    Sku SACSC-436843-ACT
    Manufact. Skusc-436843-ACT
    Packaging Unit20 µg
  8. CCDC42B CRISPR/Cas9 KO Plasmid (m)
    CCDC42B CRISPR/Cas9 KO Plasmid (m)
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    Sku SACSC-436843
    Manufact. Skusc-436843
    Packaging Unit20 µg
  9. LDLRAD1 CRISPR Activation Plasmid (m2)
    LDLRAD1 CRISPR Activation Plasmid (m2)
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    Sku SACSC-436842-ACT-2
    Manufact. Skusc-436842-ACT-2
    Packaging Unit20 µg
  10. LDLRAD1 CRISPR Activation Plasmid (m)
    LDLRAD1 CRISPR Activation Plasmid (m)
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    Sku SACSC-436842-ACT
    Manufact. Skusc-436842-ACT
    Packaging Unit20 µg
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113845 items

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