CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. CRBN CRISPR/Cas9 Lentivirus (Integrating)
    CRBN CRISPR/Cas9 Lentivirus (Integrating)
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    Sku BPS78517
    Manufact. Sku78517
    Packaging Unit500 µl x 2
  2. Kinase (Human) CRISPR/Cas9 Lentivirus (Integrating)
    Kinase (Human) CRISPR/Cas9 Lentivirus (Integrating)
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    Sku BPS78488
    Manufact. Sku78488
    Packaging Unit200 µl x 2
  3. CRISPR/Cas9 Kinase Knockout Lentivirus Library (Array Format)
    CRISPR/Cas9 Kinase Knockout Lentivirus Library (Array Format)
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    Sku BPS78487
    Manufact. Sku78487
    Packaging Unit200 µl x 649
  4. AAV9 SaCas9
    AAV9 SaCas9
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    Sku BPS78486
    Manufact. Sku78486
    Packaging Unit50 µl x 2
  5. AAV8 SaCas9
    AAV8 SaCas9
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    Sku BPS78485
    Manufact. Sku78485
    Packaging Unit50 µl x 2
  6. AAV6 SaCas9
    AAV6 SaCas9
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    Sku BPS78484
    Manufact. Sku78484
    Packaging Unit50 µl x 2
  7. AAV5 SaCas9
    AAV5 SaCas9
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    Sku BPS78483
    Manufact. Sku78483
    Packaging Unit50 µl x 2
  8. AAV3 SaCas9
    AAV3 SaCas9
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    Sku BPS78481
    Manufact. Sku78481
    Packaging Unit50 µl x 2
  9. AAV2 SaCas9
    AAV2 SaCas9
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    Sku BPS78480
    Manufact. Sku78480
    Packaging Unit50 µl x 2
  10. AAV1 SaCas9
    AAV1 SaCas9
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    Sku BPS78479
    Manufact. Sku78479
    Packaging Unit50 µl x 2
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