CRISPR

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. PKR CRISPR/Cas9 KO Plasmid (rabbit)
    PKR CRISPR/Cas9 KO Plasmid (rabbit)
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    Sku SACSC-437324
    Manufact. Skusc-437324
    Packaging Unit20 µg
  2. Granzyme A CRISPR/Cas9 KO Plasmid (bovine)
    Granzyme A CRISPR/Cas9 KO Plasmid (bovine)
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    Sku SACSC-437323
    Manufact. Skusc-437323
    Packaging Unit20 µg
  3. RasGRP1 CRISPR/Cas9 KO Plasmid (bovine)
    RasGRP1 CRISPR/Cas9 KO Plasmid (bovine)
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    Sku SACSC-437322
    Manufact. Skusc-437322
    Packaging Unit20 µg
  4. CD38 CRISPR Activation Plasmid (r2)
    CD38 CRISPR Activation Plasmid (r2)
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    Sku SACSC-437321-ACT-2
    Manufact. Skusc-437321-ACT-2
    Packaging Unit20 µg
  5. CD38 CRISPR Activation Plasmid (r)
    CD38 CRISPR Activation Plasmid (r)
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    Sku SACSC-437321-ACT
    Manufact. Skusc-437321-ACT
    Packaging Unit20 µg
  6. CD38 CRISPR/Cas9 KO Plasmid (r)
    CD38 CRISPR/Cas9 KO Plasmid (r)
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    Sku SACSC-437321
    Manufact. Skusc-437321
    Packaging Unit20 µg
  7. BRCA1 CRISPR Activation Plasmid (r2)
    BRCA1 CRISPR Activation Plasmid (r2)
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    Sku SACSC-437320-ACT-2
    Manufact. Skusc-437320-ACT-2
    Packaging Unit20 µg
  8. BRCA1 CRISPR Activation Plasmid (r)
    BRCA1 CRISPR Activation Plasmid (r)
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    Sku SACSC-437320-ACT
    Manufact. Skusc-437320-ACT
    Packaging Unit20 µg
  9. BRCA1 CRISPR/Cas9 KO Plasmid (r)
    BRCA1 CRISPR/Cas9 KO Plasmid (r)
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    Sku SACSC-437320
    Manufact. Skusc-437320
    Packaging Unit20 µg
  10. Rb CRISPR/Cas9 KO Plasmid (r)
    Rb CRISPR/Cas9 KO Plasmid (r)
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    Sku SACSC-437319
    Manufact. Skusc-437319
    Packaging Unit20 µg
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