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Applications: Ideal as a positive control for anti-CD19/CD22 Bispecific CAR evaluation in T cellsUse in transduction optimizationUse to generate anti-CD19/CD22 Bispecific CAR-T cells for research use only, not for therapeutic purposes
Description: The anti-CD19/CD22 Bispecific CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragments) of anti-CD19 (clone FMC63) and anti-CD22 (clone m971) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains.
Formulation: The lentiviruses were produced from HEK293T cells, concentrated, and resuspended in DMEM.
Storage Stability: Lentiviruses are shipped with dry ice. For long term storage, it is recommended to store the virus at -80°C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle.
Supplied As: 50 µl of anti-CD19/CD22 Bispecific CAR Lentivirus at a titer ≥ 108 TU/ml. The titer will vary with each lot; the exact value is provided with each shipment.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-2
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