Notes: 3-Methoxytyrosine is an active metabolite of L-DOPA (Item No. 13248).{64473} It is formed from L-DOPA via O-methylation by catechol-O-methyltransferase (COMT). 3-Methoxytyrosine (10 and 100 µM) inhibits L-DOPA-induced neuroprotection in primary rat mesencephalic dopaminergic neurons.{32397}