Formulation: A solution in water
Formal Name: 8-chloro-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Purity: ≥95%
Formula Markup: C10H11ClN5O13P3 • 4Na
Formula Weight: 629,6
Shelf life (days): 730
CAS Number: 793671-47-3
Notes: 8-Chloroadenosine-5’-triphosphate (8-chloro ATP) is an active metabolite of the anticancer agent 8-chloro cAMP and a derivative of the nucleotide adenosine 5’-triphosphate (ATP; Item No. 14498).{69006} It is formed from 8-chloro cAMP via 8-chloroadenosine (Item No. 35766) and mono- and diphosphate intermediates. 8-chloro ATP accumulates for up to 12 hours following application of 8-chloro cAMP or 8-chloroadenosine and is associated with inhibition of cell growth, decreases in endogenous ATP levels, and a reduction in RNA, but not DNA, synthesis in patient-derived multiple myeloma cells. It inhibits topoisomerase II-α-dependent relaxation of supercoiled pUC19 DNA when used at concentrations of 1.5 to 8 mM, as well as reduces topoisomerase II-α-catalyzed ATP hydrolysis by 50% at 1 mM, in K562 human myelocytic leukemia cells.{68366}
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