8-Chloroadenosine, CAS 34408-14-5

Formulation: A solid

Formal Name: 8-chloro-adenosine

Purity: ≥98%

Formula Markup: C10H12ClN5O4

Formula Weight: 301,7

Shelf life (days): 1460

CAS Number: 34408-14-5

Notes: 8-Chloroadenosine is a nucleoside analog and an active metabolite of the anticancer agent 8-chloro cAMP.{69006} It is formed from 8-chloro cAMP by phosphodiesterases (PDEs) and upon entry into cells, 8-chloroadenosine is phosphorylated by adenosine kinase to produce 8-chloro-ATP. 8-Chloroadenosine (10 µM) inhibits RNA, but not DNA, synthesis in vitro. It is cytotoxic to patient-derived multiple myeloma cells in a concentration-dependent manner. 8-chloroadenosine (50 mg/kg) reduces tumor growth by 50% in an HCT116 colorectal cancer mouse xenograft model.{69007}

• SKU: CAY35766-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35766-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe