Formulation: A solution in water
Formal Name: adenosine, 5′-[hydrogen P-(phosphonomethyl)phosphonate], trisodium salt
Purity: ≥98%
Formula Markup: C11H14N5O9P2 • 3Na
Formula Weight: 491,2
Shelf life (days): 730
CAS Number: 2659222-76-9
Notes: Adenosine 5'-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Ki value of 37 nM.{62213} It inhibits cAMP accumulation induced by adenosine 5'-monophosphate (AMP; Item No. 21094), adenosine 5'-diphosphate (ADP; Item Nos. 16778 / 21121), or adenosine 5'-triphosphate (ATP; Item No. 14498), but not adenosine (Item No. 21232), in VA-13 human fibroblasts when used at a concentration of 100 µM. Adenosine 5'-methylenediphosphate reduces proliferation of U-138 MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.{62214,62215} It increases tumor infiltration of CD3+CD8+ T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 µg/mouse.{62216}
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