Formulation: A solid
Formal Name: 1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
Purity: ≥98%
Formula Markup: C17H15ClN6O2
Formula Weight: 370,8
Shelf life (days): 1460
CAS Number: 1883711-97-4
Notes: AM0902 is a transient receptor potential ankyrin 1 (TRPA1) antagonist (IC50 = 0.131 µM for the human receptor in a calcium mobilization assay).{62973} It is selective for human TRPA1 over human transient receptor potential vanilloid 1 (TRPV1) and TRPV4, rat TRPV1, TRPV3, and transient receptor potential melastatin 8 (TRPM8), and a panel of 40 additional targets at 10 µM. In vivo, AM0902 (10 and 30 mg/kg) reduces the number of tail flinches induced by the TRPA1 agonist allyl isothiocyanate (AITC) in rats.