Formulation: A solid
Formal Name: 3-[(2-aminoethyl)dithio]-propanoic acid
Purity: ≥95%
Formula Markup: C5H11NO2S2
Formula Weight: 181,3
Shelf life (days): 730
CAS Number: 15579-00-7
Notes: Aminoethyl-SS-propionic acid is a cleavable disulfide linker.{66102,66103} It has been used in the synthesis of antibody-drug conjugates (ADCs) containing the antibody trastuzumab and a membrane-impermeable cytotoxin, which inhibits HER2 dimerization and induces cytotoxicity in HER2-positive breast cancer cells, respectively.{66103}