Formulation: A solid
Formal Name: 4aS,5,6,7,8,8aR,9,9aS-octahydro-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan-2(4H)-one
Purity: ≥98%
Formula Markup: C15H20O2
Formula Weight: 232,3
Shelf life (days): 1460
CAS Number: 73069-14-4
Notes: Atractylenolide II is a sesquiterpene that has been found in D. metel and has diverse biological activities.{64489,64490,64491} It inhibits proliferation of, as well as halts the cell cycle at the G2/M phase and induces apoptosis in, DU145 and LNCaP prostate cancer cells when used at concentrations of 50 and 100 µM.{64489} Atractylenolide II also inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells (IC50 = 17.73 µM).{64490} It increases Nrf2 protein levels when used at a concentration of 50 µM and reduces reactive oxygen species (ROS) production induced by irradiation in HaCaT cells.{64491} Atractylenolide II (60 mg/kg) prevents cutaneous and intestinal ulcers induced by irradiation in mice.
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