Formulation: A solid
Formal Name: (11β,12α,15β)-15-[[(2E)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-picras-3-en-21-oic acid, methyl ester
Purity: ≥95%
Formula Markup: C28H36O11
Formula Weight: 548,6
Shelf life (days): 1460
CAS Number: 41451-75-6
Notes: Bruceantin is a quassinoid originally isolated from B. antidysenterica that has diverse biological activities.{54980,42191,54981} It inhibits protein synthesis in HeLa cells, reticulocytes, and reticulocyte lysates (IC50s = 30, 40, and 1,600 nM, respectively).{54980} Bruceantin is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 8 and 13 nM, respectively).{42191} It induces apoptosis in HL-60 leukemia and RPMI-8226 multiple myeloma cells (IC50s = 12.2 and 12.8 nM, respectively).{54981} Bruceantin (5 mg/kg) induces tumor regression in an RPMI-8226 mouse xenograft model.
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