Formulation: A solid
Formal Name: 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl-1,1,2,2,3,3,4,4-d8]-8-azaspiro[4.5]decane-7,9-dione, monohydrochloride
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C21H23D8N5O2 • HCl
Formula Weight: 430
Shelf life (days): 1460
CAS Number: 1216761-39-5
Notes: Buspirone-d8 is intended for use as an internal standard for the quantification of buspirone by GC- or LC-MS. Buspirone is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A.{51675} It binds to the 5-HT1A receptor (IC50 = 5.6 nM) and inhibits forskolin-induced adenylate cyclase activity in primary CA1 hippocampal pyramidal cells. Buspirone inhibits conditioned avoidance responding in rats, as well as inhibits foot shock-induced fighting in mice.{51674} Formulations containing buspirone have been used in the treatment of generalized anxiety disorder.
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