Formulation: A solid
Formal Name: N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-hexadecanamide-13,13,14,14,15,15,16,16,16-d9
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C34H60D9NO3
Formula Weight: 549
Shelf life (days): 730
CAS Number: 2260669-52-9
Notes: C16 dihydro Ceramide-d9 (d18:0/16:0-d9) is intended for use as an internal standard for the quantification of C16 dihydro ceramide (Item No. 24369) by GC- or LC-MS. C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) (Item No. 10681) that lacks the 4,5-trans double bond.{41404} C16 dihydro Ceramide (46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome c oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome c release, or channel formation in phospholipid membranes in the absence of C16 ceramide.
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