Formulation: A solid
Formal Name: 3-[[(3,4-dichlorophenyl)amino]carbonyl]-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Purity: ≥98%
Formula Markup: C15H13Cl2NO3
Formula Weight: 326,2
Shelf life (days): 1460
CAS Number: 199735-88-1
Notes: CADD522 is an inhibitor of RUNX family transcription factor 2 (RUNX2) binding to DNA.{66071} It inhibits RUNX2 binding to osteoblast-specific element 2 (OSE2) oligonucleotides in a cell-free assay, as well as inhibits RUNX2 enrichment on matrix metalloproteinase-13 (MMP-13) promoters in MCF-7 cells when used at concentrations ranging from 100 to 1,000 nM. CADD522 (50 µM) decreases clonogenic survival in a panel of nine breast cancer cell lines. It decreases the expression of the RUNX2 target genes and metastasis markers MMP-13 and VEGF in ectopic RUNX2-expressing T47D-RUNX2 and MCF-7-RUNX2 breast cancer cells. CADD522 (20 mg/kg, i.p.) reduces tumor volume and incidence in the MMTV-PyMT transgenic mouse model of breast cancer.
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