Formulation: A solid
Formal Name: N-[(1S)-4-[(2-fluoro-1-iminoethyl)amino]-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide, monohydrochloride
Purity: ≥95%
Formula Markup: C24H27FN6O3 • HCl
Formula Weight: 503
Shelf life (days): 1460
Notes: CAY10723 is an inhibitor of peptidyl arginine deiminase 2 (PAD2; EC50 = 9.5 μM in a cellular target engagement assay).{36047} It is approximately 1.6-, 47-, and 15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively. CAY10723 inhibits histone H3 citrullination in HEK293T cells expressing human PAD2 (EC50 = 0.4 μM). It also inhibits fibrinogen citrullination in the presence of isolated human polymorphonuclear leukocytes (PMNs) or synovial fluid from patients with rheumatoid arthritis when used at a concentration of 20 µM.{62492} CAY10723 (25 µM) decreases IFN-γ production in isolated human CD4+ T cells.{65555}
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