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Application: T cell activation and expansion for downstream applications, such as cytotoxicity assays, CAR (chimeric antigen receptor)-T cell development and flow cytometry.
Background: T cells are important immune cells that have a variety of functions. T cells can eliminate infected or cancerous cells and direct the immune response by helping B lymphocytes eliminate invading pathogens. T cells play a critical role in destroying cancer cells by recognizing antigens presented on cancer cells. CAR (chimeric antigen receptor)-T cell therapy has proven to be effective against some types of cancer, even when other treatments are not effective. T cells in general are widely used in cancer and research of other human diseases. However, T cells require activation to become active and proliferate. In vitro activation typically involves the use of CD3 and CD28 antibodies, in multiple forms, to engage the T cell receptor and use a co-stimulatory protein, attempting to mimic the situation in vivo where T cells are activated by the MHC (major histocompatibility complex) and APC (antigen presenting cells). This process of activation and expansion is crucial to generate enough cells for development and clinical applications.
Description: Human T Cell Activation Reagent is a ready-to-use reagent designed for in vitro activation and expansion of human T cells. This reagent consists of soluble CD3 and CD28 antibody complexes that can bind to CD3 and CD28 on the surface of T cells, providing primary and co-stimulatory signals for T cell activation.
Storage Stability: This assay kit will perform optimally for up to 6 months from the date of receipt when the materials are stored as directed.
Supplied As: This kit is provided with enough reagents and materials for the activation of 1 x 108 or 1 x 109 T cells in 100 ml of T cell expansion media, in one reaction or multiple reactions of smaller numbers of T cells.
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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