Formulation: A solid
Purity: ≥98%
Formula Markup: C178H302N50O46 • XCF3COOH
Formula Weight: 3878,7
Shelf life (days): 1460
Notes: Cathelicidin-related antimicrobial peptide (CRAMP) (140-173) is a 34-amino acid peptide derivative of the 38-amino acid antimicrobial peptide CRAMP.{68335,68336} Mature CRAMP is formed from cleavage of the full-length peptide by cathepsin G.{68337,68338} CRAMP (140-173) (1 µg/ml) is active against K. pneumoniae in vitro.{68335} It decreases neutrophil infiltration of colonic epithelial and luminal surfaces in a porcine model of colitis when administered at a dose of 10 mg/kg.{68339} Ileal administration of CRAMP (140-173) (10 mg/kg) decreases disease severity and cecal bacterial burden and increases survival in a mouse model of C. difficile infection.{68340} However, intra-articular administration of CRAMP (140-173) (10 µl of 25 µM) also increases disease severity and induces synovitis in a mouse model of surgery-induced osteoarthritis.{68341}
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