Formulation: A 1 mg/ml solution in methanol
Formal Name: 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methyl-N-(methyl-d3)propan-1-amine, monohydrochloride
Formula Markup: C20H18D3N • HCl
Formula Weight: 314,9
Shelf life (days): 0
CAS Number: 1184983-42-3
Notes: Cyclobenzaprine-d3 (hydrochloride) (CRM) contains three deuterium atoms at the terminal methyl group. It is intended for use as an internal standard for the quantification of cyclobenzaprine (Item No. 15885) by GC- or LC-mass spectrometry. Cyclobenzaprine is a skeletal muscle relaxant that also has sedative properties.{25863,25864,25861} It has been shown to antagonize muscarinic receptors (Kis = 25, 60, and 6 nM for M1, M2, and M3, respectively), serotonin 5-HT2 receptors (Kis = 56 and 330 nM for 5-HT2C and 5-HT2B, respectively), and histamine H1 receptor (IC50 = 20 nM).{25917,25919,25918}
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