Formulation: A solution in nonane
Formal Name: 3-(2,2-dichloroethenyl)-2,2-di(methyl-d3)-cyclopropanecarboxylic acid, cyano(4-fluoro-3-phenoxyphenyl)methyl ester
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C22H12Cl2D6FNO3
Formula Weight: 440,3
Shelf life (days): 730
CAS Number: 2483831-11-2
Notes: Cyfluthrin-d6 is intended for use as an internal standard for the quantification of cyfluthrin (Item No. 24231) by GC- or LC-MS. Cyfluthrin is a pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).{36375,41867} It slowly activates rat recombinant Nav1.8 channels, delays inactivation by longer than 40 ms, and induces persistent tail currents in channels expressed in X. laevis oocytes.{36375} It also decreases the mean burst rate in rat primary neurons (IC50 = 0.99 μM, respectively).{41867} Cyfluthrin is toxic to various insects, including A. melinus, G. ashmeadi, E. eremicus, and E. formosa (LC50s = 7, 67, 96, and 63 ng/ml, respectively) and the A. sinensis mosquito (LC50 = 0.446 ppm).{41868,41869} It is also toxic to A. mellifera honeybees (LD50 = 0.22 ppm), affecting locomotor activity and wing fanning behavior with an increase in the mean bout duration of time spent upside down, indicating disruption of the righting reflex, and a decrease in wing fanning behavior when administered at a dose of 10 ng/bee.{41870} Formulations containing cyfluthrin have been used for the control of insects in agriculture and for non-commercial purposes.
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