Formulation: A solid
Formal Name: N-[(1E)-2-(2,5-dihydroxyphenyl)ethenyl]-formamide
Purity: ≥90%
Formula Markup: C9H9NO3
Formula Weight: 179,2
Shelf life (days): 1460
CAS Number: 100827-28-9
Notes: Erbstatin is an inhibitor of EGF receptor-associated tyrosine kinase that has been found in Streptomyces.{16076,66246} It is selective for EGF receptor-associated tyrosine kinase over protein kinase A (PKA) and PKC, but does inhibit phosphatidylinositol kinase (IC50s = 0.2, 100, >179, and 25 µg/ml, respectively).{16076} Erbstatin (10 µg/ml) induces apoptosis and DNA fragmentation in L1210 murine skin lymphocytic leukemia cells.{66246} It inhibits LPS-induced production of prostaglandin F2α (PGF2α; Item Nos. 16010 / 16020) and nitrite in J774.2 macrophages in a concentration-dependent manner.{1915} Erbstatin (4 mg/animal) reduces tumor growth in an MCF-7 breast cancer mouse xenograft model when used in combination with the iron chelator foroxymithine, which prevents its degradation.{66247}
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