Formulation: A solid
Formal Name: 5-(amino-15N)-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazole-5-13C-3-carbonitrile-13C-15N
Purity: ≥95%
Formula Markup: C10[13C]2H4Cl2F6N2[15N]2OS
Formula Weight: 441,1
Shelf life (days): 1460
Notes: Fipronil-13C2,15N2 is intended for use as an internal standard for the quantification of fipronil (Item No. 24128) by GC- or LC-MS. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 28 and 1,660 nM for cockroach and rat receptors, respectively).{41694} It also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.{41695} Formulations containing fipronil have been used as insecticides in veterinary care.
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