Formulation: A solid
Formal Name: (2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid
Purity: ≥98%
Formula Markup: C38H46O8
Formula Weight: 630,8
Shelf life (days): 1460
CAS Number: 173932-75-7
Notes: Gambogenic acid is a xanthone that has been found in G. hanburyi and has diverse biological activities.{69357,69358,69359,69360} It reduces the proliferation of HeLa cervical cancer and HEL erythroleukemic cells (MICs = 12.5 and 3.13 µg/ml, respectively).{69357} Gambogenic acid reduces the proliferation of, and induces apoptosis in, HepG2 hepatocellular carcinoma cells, as well as induces cell cycle arrest at the G0/G1 phase in, and decreases migration of, M14 melanoma cells, in a concentration-dependent manner.{69358,69359} Oral administration of lipid nanoparticles (LNPs) encapsulating gambogenic acid reduces tumor volume and weight in a 4T1 murine mammary carcinoma model.{69360}
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