Gap 27 (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-seryl-L-arginyl-L-prolyl-L-threonyl-L-α-glutamyl-L-lysyl-L-threonyl-L-isoleucyl-L-phenylalanyl-L-isoleucyl-L-isoleucine, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C60H101N15O17 • XCF3COOH

Formula Weight: 1304,6

Shelf life (days): 1460

Notes: Gap 27 is a connexin-mimetic peptide that corresponds to amino acids 204-214 of extracellular loop 2 in connexin 43.{64126} It reduces survival of isolated rat osteoclasts when used at a concentration of 500 µM and decreases bone resorption in rat bone slice and osteoclast co-cultures.{64127} Gap 27 accelerates wound closure and stratification of the corneal epithelium in isolated human corneas.{64128} In vivo, Gap 27 reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of arterio-venous fistula (AV-shunt) surgery-induced high-output heart failure.{64129}

• SKU: CAY35124-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35124-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe