GNE-618, CAS 1362151-42-5

Formulation: A solid

Formal Name: N-[[4-[[3-(trifluoromethyl)phenyl]sulfonyl]phenyl]methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Purity: ≥98%

Formula Markup: C21H15F3N4O3S

Formula Weight: 460,4

Shelf life (days): 1460

CAS Number: 1362151-42-5

Notes: GNE-618 is an inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC50 = 6.1 nM for the human enzyme).{69326} It reduces NAD+ levels in PC3 prostate cancer cells (EC50 = 1.2 nM) and inhibits the proliferation of A2780 ovarian cancer cells (IC50 = 4.3 nM). GNE-618 (100 mg/kg) induces tumor regression in an A2780 mouse xenograft model.

• SKU: CAY37223-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37223-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe