Formulation: A solution in water
Formal Name: guanosine, 5′-[hydrogen P-(phosphonomethyl)phosphonate], trisodium salt
Purity: ≥95%
Formula Markup: C11H14N5O10P2 • 3Na
Formula Weight: 507,2
Shelf life (days): 1460
Notes: Guanosine 5'-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73 (Ki = 410 nM for the recombinant human enzyme).{65642} It also induces tubulin polymerization when used at a concentration of 1 mM.{65643} Guanosine 5'-methylenediphosphate has been used as a precursor in the synthesis of hydrolysis-resistant affinity resins for the purification of mRNA cap-binding proteins such as eukaryotic translation initiation factor 4E (eIF4E).{65644}