Formulation: A crystalline solid
Formal Name: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
Purity: ≥98%
Formula Markup: C13H12N2O
Formula Weight: 212,3
Shelf life (days): 1460
CAS Number: 442-51-3
Notes: Peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs.{10162} Harmine is a β-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPARγ expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner.{14921} Administration of harmine (30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression (TNF-α, IL-1β, iNOS) and macrophage accumulation in adipose tissue.{14921}
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