Formulation: A solid
Formal Name: 5-deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propen-1-yl]amino]-1,2-O-methylene-D-neo-inositol
Purity: ≥95%
Formula Markup: C23H29NO12
Formula Weight: 511,5
Shelf life (days): 730
CAS Number: 6379-56-2
Notes: Hygromycin A is an antibiotic originally isolated from S. hygroscopicus.{62571} It is active against numerous spirochete bacteria, including T. pallidum, L. biflexa, and four strains of B. burgdorferi (MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies from B. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.
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