Formulation: A solid
Formal Name: 1-(2-((allyl-d5)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole, monosulfate
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C14H9Cl2D5N2O • H2SO4
Formula Weight: 400,3
Shelf life (days): 1460
CAS Number: 1398065-92-3
Notes: Imazalil-d5 (sulfate) is intended for use as an internal standard for the quantification of imazalil (Item No. 25815) by GC- or LC-MS. Imazalil is an imidazole fungicide that inhibits ergosterol biosynthesis.{36810} Imazalil inhibits the growth of various fungi in vitro including P. italicum, A. niger, U. maydis, B. alii, and C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7).{37752} It inhibits S. cerevisiae, but not rat liver microsomal, cytochrome P450 enzymes (CYPs; IC50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC50 = 0.34 μM).{36810,37753} Imazalil activates the murine pregnane X receptor (PXR) in a concentration-dependent manner in a cell-based reporter assay.{37754} It increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice when administered at a dose of 100 mg/kg. Imazalil also increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the murine constitutive androstane receptor (mCAR) agonist TCPOBOP (Item No. 14140). Formulations containing imazalil have been used to control fungal infection in agriculture.
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