Formulation: A solid
Formal Name: (OC-6-43)-dichloro[N,N-dimethyl-2-[(2-pyridinyl-κN)methylene]hydrazinecarbothioamide-κN2,κS]methoxy-indium
Purity: ≥95%
Formula Markup: C10H15Cl2InN4OS
Formula Weight: 425
Shelf life (days): 730
CAS Number: 2345755-20-4
Notes: Indium (III) thiosemicarbazone 5b is an anticancer agent.{64158} It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.
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