IWP-O1, CAS 2074607-48-8

Formulation: A solid

Formal Name: 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)-1H-1,2,3-triazole-1-acetamide

Purity: ≥98%

Formula Markup: C26H20N6O

Formula Weight: 432,5

Shelf life (days): 1460

CAS Number: 2074607-48-8

Notes: IWP-O1 is an inhibitor of porcupine (PORCN), an enzyme that catalyzes palmitoylation of Wnt proteins.{67367} It inhibits Wnt signaling in L-Wnt-STF cells (IC50 = 80 pM in a reporter assay) and phosphorylation of Dishevelled-2 (Dvl2) and Dvl3 in HeLa cells when used at a concentration of 1 µM. IWP-O1 (1 µM) enhances the cytotoxicity of the glycolysis inhibitors 2-deoxyglucose (2-DG) and lonidamine (Item No. 14640) in CAL 27 oral squamous cell carcinoma (OSCC) cells.{67368}

• SKU: CAY38418-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38418-5
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe