Notes: IXA4 is an activator of inositol-requiring enzyme 1 (IRE1).{69114} It induces the expression of the Ire1 target Xpb1s in primary mouse hepatocytes. In vivo, IXA4 (50 mg/kg) decreases hepatic expression of the Xbp1 target gene Dnajb9 in wild-type mice and a mouse model of high-fat diet-induced obesity, effects that can be reversed by the IRE1 inhibitor STF-083010 (Item No. 17370). IXA4 also increases glucose tolerance and suppresses hepatic gluconeogenesis and steatosis in a mouse model of high-fat diet-induced obesity.