KDM4D-IN-1, CAS 2098902-68-0

Formulation: A solid

Formal Name: 4,5-dihydro-2-methyl-5-oxo-pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile

Purity: ≥95%

Formula Markup: C11H7N5O

Formula Weight: 225,2

Shelf life (days): 1460

CAS Number: 2098902-68-0

Notes: KDM4D-IN-1 is an inhibitor of the histone demethylase jumonji domain-containing 2D (JMJD2D; IC50 = 0.41 µM).{67300} It is selective for JMJD2D over JMJD1B, JMJD2B, and jumonji AT rich interactive domain-containing protein 1A (JARID1A; IC50s = >10 µM for all). KDM4D-IN-1 (0.5 µM) decreases the colony formation, migration, and invasion of Caki-1 clear cell renal carcinoma cells and 786-O adenocarcinoma cells.{67301} It reduces tumor growth and vessel development in a 786-O mouse xenograft model.

• SKU: CAY37431-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37431-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe