Formulation: A solid
Formal Name: 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid, 3-[2-(3,4-dichlorophenoxy)ethyl] 5-[2-(4-morpholinyl)-1-(4-morpholinylmethyl)ethyl] ester
Purity: ≥95%
Formula Markup: C29H39Cl2N3O7
Formula Weight: 612,5
Shelf life (days): 1460
CAS Number: 727358-25-0
Notes: LAU-0901 is a platelet-activating factor (PAF) receptor antagonist.{51330},{51331} In vivo, LAU-0901 (30, 60, and 90 mg/kg) reduces infarct volume and improves neurological function in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{51330} It also reduces microglial infiltration and increases astrocytic and neuronal survival in the same model.{51331} LAU-0901 (30 mg/kg) alone, or in combination with atorvastatin (Item No. 10453), reduces tumor growth in a U87MG glioblastoma mouse orthotopic tumor model.{51332}
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